The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Saira Sakalas

Saira Sakalas, BSc, MRes

PhD Student

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 7153 5299
Lab Phone: +44 (0)20 7153 5180
Email: saira.sakalas[at]

I completed my Bachelor's degree in Molecular Biology and in Public Health at Erasmus University College (Rotterdam, NL), during which I did a summer internship at Karolinska Institute (Stockholm, Sweden) in the field of cancer biology under an Amgen fellowship. I continued with my studies at Imperial College London (UK) in Molecular Basis of Human Disease. Throughout the two projects of my Research Master's degree, I studied (1) the effect of histone acetylation on chromatin remodelling and (2) the structure and function of a lipid-binding phosphatase. In Sebastian's lab, I am studying the molecular mechanisms of Wnt/beta-catenin signalling.


Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.

Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S

Molecular Cell, 2021, 81 (16), 3246-3261.e11

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