The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Paul Hopkins

Paul Hopkins, BSc, MSc, PhD

Higher Scientific Officer

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 7153 5220
Lab Phone: +44 (0)20 7153 5180
Email: paul.hopkins[at]


Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein.

Hopkins PC

PloS One, 2013, 8 (2), e55810

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The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β.

Hopkins PC, Sáinz-Fuertes R, Lovestone S

Journal of Alzheimer's Disease : JAD, 2011, 26 (2), 239-53

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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.

Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y

Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (19), 10966-71

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Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.

Hopkins PC, Huang Y, McGuire JG, Pitas RE

Journal of Lipid Research, 2002, 43 (11), 1881-9

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Structure of a serpin-enzyme complex probed by cysteine substitutions and fluorescence spectroscopy.

Ludeman JP, Whisstock JC, Hopkins PC, Le Bonniec BF, Bottomley SP

Biophysical Journal, 2001, 80 (1), 491-7

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The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin.

Dufour EK, Denault JB, Bissonnette L, Hopkins PC, Lavigne P, Leduc R

The Journal of Biological Chemistry, 2001, 276 (42), 38971-9

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Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C.

Hopkins PC, Pike RN, Stone SR

Journal of Molecular Evolution, 2000, 51 (5), 507-15

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Serpin-like properties of alpha1-antitrypsin Portland towards furin convertase.

Dufour EK, Denault JB, Hopkins PC, Leduc R

FEBS Letters, 1998, 426 (1), 41-6

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Alpha 1-antitrypsin polymerisation can occur by both loop A and C sheet mechanisms.

Bottomley SP, Hopkins PC, Whisstock JC

Biochemical and Biophysical Research Communications, 1998, 251 (1), 1-5

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Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins.

Chang WS, Whisstock J, Hopkins PC, Lesk AM, Carrell RW, Wardell MR

Protein Science : a Publication of the Protein Society, 1997, 6 (1), 89-98

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Inhibitory mechanism of serpins. Mobility of the C-terminal region of the reactive-site loop.

Hopkins PC, Chang WS, Wardell MR, Stone SR

The Journal of Biological Chemistry, 1997, 272 (7), 3905-9

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Serpins. A mechanistic class of their own.

Stone SR, Whisstock JC, Bottomley SP, Hopkins PC

Advances in Experimental Medicine and Biology, 1997, 425, 5-15

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Role of the P2 residue in determining the specificity of serpins.

Djie MZ, Le Bonniec BF, Hopkins PC, Hipler K, Stone SR

Biochemistry, 1996, 35 (35), 11461-9

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The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase.

Hopkins PC, Stone SR

Biochemistry, 1995, 34 (48), 15872-9

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Development of a novel recombinant serpin with potential antithrombotic properties.

Hopkins PC, Crowther DC, Carrell RW, Stone SR

The Journal of Biological Chemistry, 1995, 270 (20), 11866-71

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Function of maspin.

Hopkins PC, Whisstock J

Science (New York, N.Y.), 1994, 265 (5180), 1893-4

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Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.

Betz A, Hopkins PC, Le Bonniec BF, Stone SR

The Biochemical Journal, 1994, 298 ( Pt 2), 507-10

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Reduced levels of 5-HT3 receptor recognition sites in the putamen of patients with Huntington's disease.

Steward LJ, Bufton KE, Hopkins PC, Davies WE, Barnes NM

European Journal of Pharmacology, 1993, 242 (2), 137-43

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Effects of mutations in the hinge region of serpins.

Hopkins PC, Carrell RW, Stone SR

Biochemistry, 1993, 32 (30), 7650-7

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