The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Nafiseh Chalabi Hagkarim

Nafiseh Chalabi Hagkarim, BSc, MSc, PhD

Postdoctoral Fellow

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 6109
Lab Phone: +44 (0)20 3437 6109
Email: Nafiseh.ChalabiHagkarim[at]

Dr Nafiseh Chalabi joined Sebastian's lab in August 2023 as a Postdoctoral Fellow to investigate the molecular mechanisms of the Wnt/β-catenin signalling pathway in normal and cancer cells. Prior to joining ICR, she was a Postdoctoral Research Fellow at the laboratory of Dr Roger Grand at the University of Birmingham where she also obtained her PhD studying the DNA damage response. Her PhD research focussed on the role of CCR4-NOT complex in the DNA damage response (DDR), and how disruption of this complex contributes to transcription-mediated genome instability. Her current research mainly focusses on understanding the mechanisms of the β-catenin destruction complex.


The Promotion of Genomic Instability in Human Fibroblasts by Adenovirus 12 Early Region 1B 55K Protein in the Absence of Viral Infection.

Abualfaraj T, Hagkarim NC, Hollingworth R, Grange L, Jhujh S, Stewart GS, Grand RJ

Viruses, 2021, 13 (12)

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The Regulatory Properties of the Ccr4-Not Complex.

Chalabi Hagkarim N, Grand RJ

Cells, 2020, 9 (11)

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Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection.

Chalabi Hagkarim N, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ

Journal of Virology, 2018, 92 (12)

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