Divisions of Structural Biology and Cancer Biology
The Institute of Cancer Research
Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7406
Lab Phone: +44 (0)20 7153 5180
Email: michael.ranes[at]icr.ac.uk
I received my MSc degree in Medical Biology in 2009 from the Radboud University in Nijmegen, the Netherlands. I then moved to the Clare Hall Laboratories at the London Research Institute (now part of The Francis Crick Institute), where I obtained my PhD in Biochemistry while working on transcription-coupled DNA repair mechanisms in the lab of Dr Jesper Svejstrup. In 2014, I joined the Guettler lab as a Postdoc working on the molecular mechanisms of Wnt/β-catenin signalling pathway, including its regulation by the ADP-ribosyltransferase tankyrase. In January 2023, I will be launching my own research team at the Biochemistry Department of the University of Oxford.
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S
Molecular Cell, 2021, 81 (16), 3246-3261.e11
View on PubMed »Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ
Nature Communications, 2018, 9 (1), 1849
View on PubMed »Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.
Pollock K, Ranes M, Collins I, Guettler S
Methods in Molecular Biology (Clifton, N.J.), 2017, 1608, 445-473
View on PubMed »A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari PO, Stewart A, Giglia-Mari G, Snijders AP, Vermeulen W, Svejstrup JQ
Nucleic Acids Research, 2016, 44 (11), 5246-55
View on PubMed »Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.
Mariotti L, Templeton CM, Ranes M, Paracuellos P, Cronin N, Beuron F, Morris E, Guettler S
Molecular Cell, 2016, 63 (3), 498-513
View on PubMed »Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.
Wang Y, Chakravarty P, Ranes M, Kelly G, Brooks PJ, Neilan E, Stewart A, Schiavo G, Svejstrup JQ
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (40), 14454-9
View on PubMed »New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.
Jimeno S, Tous C, García-Rubio ML, Ranes M, González-Aguilera C, Marín A, Aguilera A
Molecular and Cellular Biology, 2011, 31 (4), 674-85
View on PubMed »