The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Michael Ranes

Michael Ranes, BSc, MSc, PhD

Postdoctoral Fellow

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7406
Lab Phone: +44 (0)20 7153 5180
Email: michael.ranes[at]icr.ac.uk

Research Gate   

Michael received his MSc degree in Medical Biology in 2009 from the Radboud University in Nijmegen, the Netherlands. He then moved to the Clare Hall Laboratories at the London Research Institute (now part of The Francis Crick Institute), where he obtained his PhD in Biochemistry while working on transcription-coupled DNA repair mechanisms in the lab of Dr Jesper Svejstrup. In 2014, he joined the Guettler lab as a Postdoc working on understanding how the poly(ADP-ribose)polymerase tankyrase regulates the Wnt/β-catenin signalling pathway.

Awards and Honors

  • Cum Laude MSc degree in Medical Biology (2009)

Publications

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ

Nature Communications, 2018, 9 (1), 1849

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Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.

Pollock K, Ranes M, Collins I, Guettler S

Methods in Molecular Biology (Clifton, N.J.), 2017, 1608, 445-473

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A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.

Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari PO, Stewart A, Giglia-Mari G, Snijders AP, Vermeulen W, Svejstrup JQ

Nucleic Acids Research, 2016, 44 (11), 5246-55

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Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.

Mariotti L, Templeton CM, Ranes M, Paracuellos P, Cronin N, Beuron F, Morris E, Guettler S

Molecular Cell, 2016, 63 (3), 498-513

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Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.

Wang Y, Chakravarty P, Ranes M, Kelly G, Brooks PJ, Neilan E, Stewart A, Schiavo G, Svejstrup JQ

Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (40), 14454-9

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New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.

Jimeno S, Tous C, García-Rubio ML, Ranes M, González-Aguilera C, Marín A, Aguilera A

Molecular and Cellular Biology, 2011, 31 (4), 674-85

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