The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Matthew Jessop

Matthew Jessop, BSc, PhD

Postdoctoral Fellow

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 7153 5236
Lab Phone: +44 (0)20 7153 5180
Email: matthew.jessop[at]

I completed my BSc (Hons) in Biology at the University of Auckland, New Zealand, in 2015. I then moved to the Institut de Biologie Structurale in Grenoble, France, for my PhD, working in Dr Irina Gutsche’s group. During my PhD, I used cryo-EM and biochemistry to characterise the bacterial AAA+ ATPase RavA and the Mitochondrial Complex I Assembly Complex. I moved to the Guettler lab in 2020 to work on the cryo-EM characterisation of tankyrase.


Structural basis of tankyrase activation by polymerization.

Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Desfosses A, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S

Nature, 2022, 612 (7938), 162-169

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AAA+ ATPases: structural insertions under the magnifying glass.

Jessop M, Felix J, Gutsche I

Current Opinion in Structural Biology, 2021, 66, 119-128

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Assembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination.

Giachin G, Jessop M, Bouverot R, Acajjaoui S, Saïdi M, Chretien A, Bacia-Verloop M, Signor L, Mas PJ, Favier A, Borel Meneroud E, Hons M, Hart DJ, Kandiah E, Boeri Erba E, Buisson A, Leonard G, Gutsche I, Soler-Lopez M

Angewandte Chemie (International Ed. in English), 2021, 60 (9), 4689-4697

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Supramolecular assembly of the Escherichia coli LdcI upon acid stress.

Jessop M, Liesche C, Felix J, Desfosses A, Baulard M, Adam V, Fraudeau A, Huard K, Effantin G, Kleman JP, Bacia-Verloop M, Bourgeois D, Gutsche I

Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (2)

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Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.

Jessop M, Arragain B, Miras R, Fraudeau A, Huard K, Bacia-Verloop M, Catty P, Felix J, Malet H, Gutsche I

Communications Biology, 2020, 3 (1), 46

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The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis.

Laddomada F, Miyachiro MM, Jessop M, Patin D, Job V, Mengin-Lecreulx D, Le Roy A, Ebel C, Breyton C, Gutsche I, Dessen A

Scientific Reports, 2019, 9 (1), 4656

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Atomic structures of an entire contractile injection system in both the extended and contracted states.

Desfosses A, Venugopal H, Joshi T, Felix J, Jessop M, Jeong H, Hyun J, Heymann JB, Hurst MRH, Gutsche I, Mitra AK

Nature Microbiology, 2019, 4 (11), 1885-1894

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