Structural basis of tankyrase activation by polymerization.
Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Desfosses A, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S
Nature, 2022, 612 (7938), 162-169
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Mariola Zaleska, BSc, MSc, PhD
Senior Scientific Officer
Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7539
Lab Phone: +44 (0)20 3437 7539
Email: mariola.zaleska[at]icr.ac.uk
Research Gate NCBI Bibliography
I studied Biotechnology (BSc) at the University of Silesia in Poland and undertook my MSc in Analytical Bioscience at the University of Huddersfield. I obtained my PhD in Dr Mark Pfuhl’s lab at King’s College London where I investigated the function of the MS1 protein, a cardiac stress response factor. For my postdoctoral research, I joined Dr Rachel Tribe’s lab at King’s College London where I studied expression of Kv7 potassium channels in the human myometrium. I then joined Dr Tony Jackson’s lab at the University of Cambridge where I characterised the role of extracellular loops of Nav sodium channels. I joined Sebastian’s lab in July 2017.
Publications
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S
Molecular Cell, 2021, 81 (16), 3246-3261.e11
View on PubMed »Solution NMR assignment of the ARC4 domain of human tankyrase 2.
Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M
Biomolecular NMR Assignments, 2019, 13 (1), 255-260
View on PubMed »Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.
Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S
Scientific Reports, 2019, 9 (1), 19130
View on PubMed »The Voltage-Dependent Sodium Channel Family
Zaleska M, Salvage SC, Thomson AJ, Namadurai S, Huang CL, Wilkinson T, Cusdin FS, Jackson AP
The Oxford Handbook of Neuronal Ion Channels., 2018, [published online ahead of print]
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Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.
Ababou A, Zaleska M
Archives of Biochemistry and Biophysics, 2015, 587, 61-9
View More »Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.
Ababou A, Zaleska M
Archives of Biochemistry and Biophysics, 2015, 587, 61-9
View on PubMed »The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.
Zaleska M, Fogl C, Kho AL, Ababou A, Ehler E, Pfuhl M
PloS One, 2015, 10 (12), e0144614
View on PubMed »A structural and functional dissection of the cardiac stress response factor MS1.
Fogl C, Puckey L, Hinssen U, Zaleska M, El-Mezgueldi M, Croasdale R, Bowman A, Matsukawa A, Samani NJ, Savva R, Pfuhl M
Proteins, 2012, 80 (2), 398-409
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