Structural basis of tankyrase activation by polymerization.
Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Desfosses A, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S
Nature, 2022, 612 (7938), 162-169
View on PubMed »Divisions of Structural Biology and Cancer Biology
The Institute of Cancer Research
Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7539
Lab Phone: +44 (0)20 3437 7539
Email: mariola.zaleska[at]icr.ac.uk
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I studied Biotechnology (BSc) at the University of Silesia in Poland and undertook my MSc in Analytical Bioscience at the University of Huddersfield. I obtained my PhD in Dr Mark Pfuhl’s lab at King’s College London where I investigated the function of the MS1 protein, a cardiac stress response factor. For my postdoctoral research, I joined Dr Rachel Tribe’s lab at King’s College London where I studied expression of Kv7 potassium channels in the human myometrium. I then joined Dr Tony Jackson’s lab at the University of Cambridge where I characterised the role of extracellular loops of Nav sodium channels. I joined Sebastian’s lab in July 2017.
Structural basis of tankyrase activation by polymerization.
Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Desfosses A, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S
Nature, 2022, 612 (7938), 162-169
View on PubMed »Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S
Molecular Cell, 2021, 81 (16), 3246-3261.e11
View on PubMed »Solution NMR assignment of the ARC4 domain of human tankyrase 2.
Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M
Biomolecular NMR Assignments, 2019, 13 (1), 255-260
View on PubMed »Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.
Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S
Scientific Reports, 2019, 9 (1), 19130
View on PubMed »The Voltage-Dependent Sodium Channel Family
Zaleska M, Salvage SC, Thomson AJ, Namadurai S, Huang CL, Wilkinson T, Cusdin FS, Jackson AP
The Oxford Handbook of Neuronal Ion Channels., 2018, [published online ahead of print]
Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.
Ababou A, Zaleska M
Archives of Biochemistry and Biophysics, 2015, 587, 61-9
View More »Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.
Ababou A, Zaleska M
Archives of Biochemistry and Biophysics, 2015, 587, 61-9
View on PubMed »The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.
Zaleska M, Fogl C, Kho AL, Ababou A, Ehler E, Pfuhl M
PloS One, 2015, 10 (12), e0144614
View on PubMed »A structural and functional dissection of the cardiac stress response factor MS1.
Fogl C, Puckey L, Hinssen U, Zaleska M, El-Mezgueldi M, Croasdale R, Bowman A, Matsukawa A, Samani NJ, Savva R, Pfuhl M
Proteins, 2012, 80 (2), 398-409
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