The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Mariola Zaleska

Mariola Zaleska, BSc, MSc, PhD

Senior Scientific Officer

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7539
Lab Phone: +44 (0)20 3437 7539
Email: mariola.zaleska[at]icr.ac.uk

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I studied Biotechnology (BSc) at the University of Silesia in Poland and undertook my MSc in Analytical Bioscience at the University of Huddersfield. I obtained my PhD in Dr Mark Pfuhl’s lab at King’s College London where I investigated the function of the MS1 protein, a cardiac stress response factor. For my postdoctoral research, I joined Dr Rachel Tribe’s lab at King’s College London where I studied expression of Kv7 potassium channels in the human myometrium. I then joined Dr Tony Jackson’s lab at the University of Cambridge where I characterised the role of extracellular loops of Nav sodium channels. I joined Sebastian’s lab in July 2017.

Publications

Structural basis of tankyrase activation by polymerization.

Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Desfosses A, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S

Nature, 2022, 612 (7938), 162-169

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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.

Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S

Molecular Cell, 2021, 81 (16), 3246-3261.e11

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Solution NMR assignment of the ARC4 domain of human tankyrase 2.

Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M

Biomolecular NMR Assignments, 2019, 13 (1), 255-260

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Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S

Scientific Reports, 2019, 9 (1), 19130

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Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.

Ababou A, Zaleska M

Archives of Biochemistry and Biophysics, 2015, 587, 61-9

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Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.

Ababou A, Zaleska M

Archives of Biochemistry and Biophysics, 2015, 587, 61-9

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The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.

Zaleska M, Fogl C, Kho AL, Ababou A, Ehler E, Pfuhl M

PloS One, 2015, 10 (12), e0144614

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A structural and functional dissection of the cardiac stress response factor MS1.

Fogl C, Puckey L, Hinssen U, Zaleska M, El-Mezgueldi M, Croasdale R, Bowman A, Matsukawa A, Samani NJ, Savva R, Pfuhl M

Proteins, 2012, 80 (2), 398-409

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