The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Mariola Zaleska

Mariola Zaleska, BSc, MSC, PhD

Higher Scientific Officer

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7539
Lab Phone: +44 (0)20 3437 7539
Email: mariola.zaleska[at]

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Mariola studied Biotechnology (BSc) at the University of Silesia in Poland and undertook her MSc in Analytical Bioscience at the University of Huddersfield. She then did her PhD in Dr Mark Pfuhl’s lab at King’s College London where she investigated the function of MS1 protein, a cardiac stress response factor. For her postdoctoral research, she joined Dr Rachel Tribe’s lab at King’s College London where she studied expression of Kv7 potassium channels in human myometrium. She then joined Dr Tony Jackson’s lab at University of Cambridge where she characterised the role of extracellular loops of Nav sodium channels. Mariola joined Sebastian’s lab in July 2017.


The Voltage-Dependent Sodium Channel Family

Zaleska M, Salvage SC, Thomson AJ, Namadurai S, Huang CL, Wilkinson T, Cusdin FS, Jackson AP

The Oxford Handbook of Neuronal Ion Channels., 2018, [published online ahead of print]

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On the Ca2+ binding and conformational change in EF-hand domains: Experimental evidence of Ca2+-saturated intermediates of N-domain of calmodulin.

Ababou A, Zaleska M, Pfuhl M

Biochimica Et Biophysica Acta. Proteins and Proteomics, 2017, 1865 (6), 640-651

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Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.

Ababou A, Zaleska M

Archives of Biochemistry and Biophysics, 2015, 587, 61-9

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The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.

Zaleska M, Fogl C, Kho AL, Ababou A, Ehler E, Pfuhl M

PloS One, 2015, 10 (12), e0144614

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A structural and functional dissection of the cardiac stress response factor MS1.

Fogl C, Puckey L, Hinssen U, Zaleska M, El-Mezgueldi M, Croasdale R, Bowman A, Matsukawa A, Samani NJ, Savva R, Pfuhl M

Proteins, 2012, 80 (2), 398-409

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