The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

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Mariola Zaleska

Mariola Zaleska, BSc, MSc, PhD

Higher Scientific Officer

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 7539
Lab Phone: +44 (0)20 3437 7539
Email: mariola.zaleska[at]icr.ac.uk

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I studied Biotechnology (BSc) at the University of Silesia in Poland and undertook my MSc in Analytical Bioscience at the University of Huddersfield. I obtained my PhD in Dr Mark Pfuhl’s lab at King’s College London where I investigated the function of the MS1 protein, a cardiac stress response factor. For my postdoctoral research, I joined Dr Rachel Tribe’s lab at King’s College London where I studied expression of Kv7 potassium channels in the human myometrium. I then joined Dr Tony Jackson’s lab at the University of Cambridge where I characterised the role of extracellular loops of Nav sodium channels. I joined Sebastian’s lab in July 2017.

Publications

Solution NMR assignment of the ARC4 domain of human tankyrase 2.

Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M

Biomolecular NMR Assignments, 2019, 13 (1), 255-260

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Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S

Scientific Reports, 2019, 9 (1), 19130

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The Voltage-Dependent Sodium Channel Family

Zaleska M, Salvage SC, Thomson AJ, Namadurai S, Huang CL, Wilkinson T, Cusdin FS, Jackson AP

The Oxford Handbook of Neuronal Ion Channels., 2018, [published online ahead of print]

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Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.

Ababou A, Zaleska M

Archives of Biochemistry and Biophysics, 2015, 587, 61-9

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Electrostatics effects on Ca(2+) binding and conformational changes in EF-hand domains: Functional implications for EF-hand proteins.

Ababou A, Zaleska M

Archives of Biochemistry and Biophysics, 2015, 587, 61-9

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The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.

Zaleska M, Fogl C, Kho AL, Ababou A, Ehler E, Pfuhl M

PloS One, 2015, 10 (12), e0144614

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A structural and functional dissection of the cardiac stress response factor MS1.

Fogl C, Puckey L, Hinssen U, Zaleska M, El-Mezgueldi M, Croasdale R, Bowman A, Matsukawa A, Samani NJ, Savva R, Pfuhl M

Proteins, 2012, 80 (2), 398-409

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