The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Current Lab

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Keerthiraju Ravichandran

Keerthiraju Ravichandran, B.Tech, MRes, PhD

Postdoctoral Fellow

Location: 237 Fulham Road, London, SW3 6JB
Office Phone: +44 (0)20 3437 3544
Lab Phone: +44 (0)20 7153 5180
Email: keerthiraju.ravichandran[at]

Research Gate   

I completed my B.Tech in Chemical Engineering from Anna University in Chennai, India, in 2013. Following my interest in sustainable bioenergy, I pursued an MRes in Sustainable Bioenergy at the School of Biosciences, University of Nottingham, UK, from 2014 to 2016. During my time there, I had the opportunity to intern at the Flow Cytometry Facility based in Queens Medical Centre in Nottingham, which inspired me to pursue higher research studies in basic science. Motivated by my newfound passion, I embarked on a PhD in the prestigious Max Planck Research Group, based at the Malopolska Centre of Biotechnology in Krakow, Poland. My doctoral research focussed on unravelling the mysteries of an ancient ubiquitin-like protein (Urm1) conjugation mechanism called urmylation. To investigate its function, I employed crystallography, mass spectrometry, and biochemical assays, successfully deciphering the intricate workings of urmylation. In May 2023, I joined the Guettler lab to study the molecular mechanisms of the Wnt/beta-catenin signalling pathway.


E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.

Ravichandran KE, Kaduhr L, Skupien-Rabian B, Shvetsova E, Sokołowski M, Krutyhołowa RC, Kwasna D, Brachmann C, Lin S, Guzman Perez S, Wilk P, Kösters M, Grudnik P, Jankowska U, Leidel SA, Schaffrath R, Glatt S

The EMBO Journal, 2022, 41 (20), e111318

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Urm1, not quite a ubiquitin-like modifier?

Kaduhr L, Brachmann C, Ravichandran KE, West JD, Glatt S, Schaffrath R

Microbial Cell (Graz, Austria), 2021, 8 (11), 256-261

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Redox requirements for ubiquitin-like urmylation of Ahp1, a 2-Cys peroxiredoxin from yeast.

Brachmann C, Kaduhr L, Jüdes A, Ravichandran KE, West JD, Glatt S, Schaffrath R

Redox Biology, 2020, 30, 101438

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Molecular basis for the bifunctional Uba4-Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation.

Pabis M, Termathe M, Ravichandran KE, Kienast SD, Krutyhołowa R, Sokołowski M, Jankowska U, Grudnik P, Leidel SA, Glatt S

The EMBO Journal, 2020, 39 (19), e105087

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Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer.

Hawer H, Hammermeister A, Ravichandran KE, Glatt S, Schaffrath R, Klassen R

Genes, 2018, 10 (1)

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