The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Cryo-EM reveals structural basis of tankyrase activation by polymerisation

In our latest paper, we report structure-function studies that reveal how tankyrase is turned from a sluggish to an active protein by filamentous polymerisation. You can read the open-access paper here. The paper comes with a press release by ICR. Congratulations to the team!

We have a Postdoc position available, with a project centred on studying the mechanisms of site-specific ADP-ribosylation in Wnt/beta-catenin signalling and telomere maintenance. Details can be found here. The application period closes on the 6th of November 2022.

Come and join us! We have an MRC iCASE PhD Studentship available in our team. In collaboration with AstraZeneca, you will develop novel means to probe the function of one of our favourite proteins. More information can be found here. Application deadline is the 13th of November 2022.

We welcome Shafayat Azad to our team. Shaf joins us as a PhD Student and will investigate the mechanisms of telomere maintenance.

Michael Ranes speaks at the inaugural “Black in Cancer” conference – an international collaboration between Black in Cancer and Cancer Research UK, one of our major funders.

Last month, we celebrated Yexin’s PhD graduation. Many congratulations Yexin on your well-deserved PhD, and all the best for your next steps!

After almost three years in the lab, Nisha is moving on. We say thank you and goodbye – all the best for the future! Stay tuned for exciting publication news coming soon.

We say thank you and farewell to Euan Colaco Osorio, who joined us for almost two months as a Summer Student funded by the Lister Institute. All the best for your next adventure!

PhD Student Iona Black has has been awarded the Best Poster prize at the 37th American Chemical Society Medicinal Chemistry Symposium held in New York City in June 2022. To attend the conference, Iona received a Royal Society of Chemistry researcher development grant of £500. Many congratulations Iona!

Our first lab retreat in a long time: two days of science and sunshine … and lots of food.