Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S
Molecular Cell, 2021
View on PubMed »Divisions of Structural Biology and Cancer Biology
The Institute of Cancer Research
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S
Molecular Cell, 2021
View on PubMed »ADP-ribosyltransferases, an update on function and nomenclature.
Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M
The FEBS Journal, 2021
View on PubMed »Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.
Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S
Scientific Reports, 2019, 9 (1), 19130
View on PubMed »Solution NMR assignment of the ARC4 domain of human tankyrase 2.
Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M
Biomolecular NMR Assignments, 2019
View on PubMed »Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F
Structure (London, England : 1993), 2018, 26 (8), 1101-1115.e6
View on PubMed »Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.
Mariotti L, Pollock K, Guettler S
British Journal of Pharmacology, 2017, 174 (24), 4611-4636
View on PubMed »Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.
Pollock K, Ranes M, Collins I, Guettler S
Methods in Molecular Biology (Clifton, N.J.), 2017, 1608, 445-473
View on PubMed »Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.
Mariotti L, Templeton CM, Ranes M, Paracuellos P, Cronin N, Beuron F, Morris E, Guettler S
Molecular Cell, 2016, 63 (3), 498-513
View on PubMed »AXIN Shapes Tankyrase ARChitecture.
Guettler S
Structure (London, England : 1993), 2016, 24 (10), 1625-1627
View on PubMed »The ICR conference was back in its in-person format this June, with great talks, the opportunity to network, food and of course the iconic ceilidh dancing.
Congratulations to our team member Yexin Xie for successfully defending her PhD thesis! Well done!
A fully funded PhD studentship on the mechanisms of telomere protection and length homeostasis is available in our team. For details and to apply, check out the ICR website. Application deadline is the 14th of November 2021.
Our reconstitution of the beta-catenin destruction complex made it to ICR’s ten featured scientific achievements of 2021. What a nice way to end the lab year and a real testament to the team’s work! You can find all research highlights on the ICR website.
For Black in Cancer Week, ICR’s Science Communications Officer Juanita Bawagan spoke to our team member Dr Michael Ranes about the importance of diversity in cancer research for science and society. You can read the article here.
Our Postdoc Michael Ranes will present his work at the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center. Here are the seminar details:
“Molecular mechanisms of Wnt signaling: reducing complexity”.
https://unccn.zoom.us/webinar/register/WN_2oM9nhM8Sz-xBL9QgGuXCg/
Sep 22, 2021 11:00 AM in Eastern Time (US and Canada)
The ICR has featured our latest paper in its news stream on the ICR website.
We spoke with Molecular Cell about our latest paper, “Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation,” personal experiences in science, our lab’s research and the people behind our science. Read the interview here.
Our latest paper, reporting the biochemical reconstitution of the beta-catenin destruction complex, is now published online. Congratulations to Michael, Mariola, Saira and Ruth! You can find the open access article here.
The Institute of Cancer Research surveyed 239 of its researchers to gain insights into the impact of the COVID-19 pandemic on their research, and to point to possible solutions. Read the results here.
Exciting news: our new Glacios cryo-electron microscope has arrived and is being installed. The photo pictures Basil Greber, a new Team Leader in the Division of Structural Biology, with the microscope in its new home. A new era of Structural Biology at the ICR!
In October, we welcomed three new PhD students to the lab: Saira, Ben and Giacomo! Exciting times!
Iona Black, PhD student in the lab, has been interviewed as part of the #KickstartICR appeal. You can read the interview here. To learn more about how you can help ICR to kick-start research after lockdown, please visit the Kick-Start Appeal website.
We are back to the lab since June, with a rotation system to limit occupancy, but our research can go on. Our recent (socially distanced) lab picnic in the nearby Hyde Park was a nice summer treat.
We recently welcomed three new team members: Lucie Vyletova and Paul Hopkins join us for some time as Higher Scientific Officers. Matthew Jessop started his postdoctoral research. Welcome Lucie, Paul and Matthew!
Today we welcome our new Postdoctoral Fellow Nisha Pillay to the group. Nisha joins us from the University of Manchester, having studied the molecular determinants of PARG inhibitor sensitivity for her PhD. Welcome Nisha!
Our latest paper is out: Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase. Thank you to our collaborators Ian Collins (ICR) and Mark Pfuhl (King’s College London)! Many congratulations to the whole team, in particular first author Katie Pollock on her PhD work! You can read about the work in this ICR press release.
We have a PhD studentship available to study the functions of ADP-ribosylation in telomere maintenance. For further information and to apply, visit the ICR PhD Studentships website. Applications close on the 27th of March 2022.
PhD student Yexin Xie has been awarded a place at the EMBO Course “Practical Integrative Structural Biology”. The course takes place at EMBL Hamburg and the Centre for Structural Systems Biology. Congratulations Yexin!
Postdoctoral Fellow Michael Ranes has been awarded a place at the prestigious Pathways to Independence training programme, a joint initiative by the ICR, Sanger, MRC, and Cancer Research UK institutes and the Babraham Institute. The programme provides training for future scientific leaders. Michael has also received a £5,000 Dean’s Award to develop his independent research programme. Congratulations Michael!
Our lab is growing. We welcome Oviya Inian and William (Billy) Fisher into the lab. Oviya is a Postdoctoral Fellow who joins our telomere team. Billy joins us for a two-month summer project funded by a Lister Institute Summer Studentship.