The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

Thank you and goodbye to Nisha!

After almost three years in the lab, Nisha is moving on. We say thank you and goodbye – all the best for the future! Stay tuned for exciting publication news coming soon.

We say thank you and farewell to Euan Colaco Osorio, who joined us for almost two months as a Summer Student funded by the Lister Institute. All the best for your next adventure!

PhD Student Iona Black has has been awarded the Best Poster prize at the 37th American Chemical Society Medicinal Chemistry Symposium held in New York City in June 2022. To attend the conference, Iona received a Royal Society of Chemistry researcher development grant of £500. Many congratulations Iona!

Our reconstitution of the beta-catenin destruction complex made it to ICR’s ten featured scientific achievements of 2021. What a nice way to end the lab year and a real testament to the team’s work! You can find all research highlights on the ICR website.

A fully funded PhD studentship on the mechanisms of telomere protection and length homeostasis is available in our team. For details and to apply, check out the ICR website. Application deadline is the 14th of November 2021.

For Black in Cancer Week, ICR’s Science Communications Officer Juanita Bawagan spoke to our team member Dr Michael Ranes about the importance of diversity in cancer research for science and society. You can read the article here.

Our Postdoc Michael Ranes will present his work at the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center. Here are the seminar details:

“Molecular mechanisms of Wnt signaling: reducing complexity”.
https://unccn.zoom.us/webinar/register/WN_2oM9nhM8Sz-xBL9QgGuXCg/
Sep 22, 2021 11:00 AM in Eastern Time (US and Canada)

The ICR has featured our latest paper in its news stream on the ICR website.

We spoke with Molecular Cell about our latest paper, “Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation,” personal experiences in science, our lab’s research and the people behind our science. Read the interview here.

Our latest paper, reporting the biochemical reconstitution of the beta-catenin destruction complex, is now published online. Congratulations to Michael, Mariola, Saira and Ruth! You can find the open access article here.