The Guettler Lab

Divisions of Structural Biology and Cancer Biology

The Institute of Cancer Research

New equipment for in situ structural biology

Our Light Microscopy and Electron Microscopy Facilities at ICR are being upgraded to include new equipment for in situ Structural Biology by cryogenic correlative light and electron microscopy and cryo-electron tomography. Exciting times ahead!

In the end of April, we enjoyed our inaugural WntUK meeting at the Francis Crick Institute. WntUK is a new initiative to bring together UK researchers working on all aspects of Wnt signalling for networking and exchange of ideas.

Our recent research on tankyrase is featured in the 2022/23 annual report of the Diamond Light Source (DLS) and the Electron Bio-Imaging Centre (eBIC). The work has also been selected amongst the featured scientific achievements of ICR in 2022/23. Enjoy the read!

This year’s lab trip took us to the Surrey Hills, where we enjoyed autumn colours, beautiful views, friendly bovines and glorious mud. The best scientific ideas are not born at the desk.

This summer and autumn, we welcomed two new lab members: Nafiseh Chalabi Hagkarim joins us as a Postdoctoral Fellow, and Katy Miller is embarking on her PhD. Welcome Nafis and Katy!

On the 24th of November, Sebastian delivered his inaugural lecture at the ICR, titled “Encoding the Language of Signalling Proteins” – a great occasion for colleagues, team members, mentors, friends and family to convene and celebrate! Thank you to everyone who came!

This summer, we welcomed two students to our lab. Dylan Clements learned about the daily lives of biochemists and structural biologists during his week-long stay. Sofia Savastano spent a seven-week Lister-Institute funded Summer Studentship with us, joining forces with Matt to have fun with tankyrase.

Ben, Saira and Sebastian presented the latest of the lab’s Wnt signalling work at this year’s Gordon Research Seminar and Conference in Barcelona. Ben spoke at the Gordon Research Seminar, and both Ben and Saira presented a poster at the Conference. A fantastic week of science and connecting with old and new friends in the field!

Keerthiraju Ravichandran joins us as a Postdoctoral Fellow after completing his PhD in the Max Planck Research Group at the Malopolska Centre of Biotechnology in Krakow, Poland. Welcome Raj!

Congratulations to Muhammed Kocak, who has successfully defended his PhD thesis!